ABHD12 hydrolyzes lysophosphatidylserine (LysoPS) as a LysoPS lipase (LysoPS-specific lysophospholipase) and its genetic deletion or mutation increases LysoPS in the brain, leading to symptoms reminiscent of PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts) [75]. Here, ABHD12 is linked to polyneuropathy.