Considering that mutations in the human PNPLA6, PNPLA8, or PNPLA9 are linked to neurodegenerative diseases [1,4,5,11], it is tempting to speculate that disturbed phospholipid catabolism and turnover would commonly underly the neurodegenerative phenotypes caused by loss of this enzyme family in both mice and humans. This evidence concerns the gene PNPLA6 and neurodegenerative disease.