In human HCC (obtained from patients who had been treated in the Hepatobiliary Pancreatic Division, Department of Surgery, the University of Tokyo Hospital [60]) (Table S1), the expression levels of PNPLA7 and PNPLA8, but not PNPLA6 and PNPLA9, were significantly lower in tumor tissues than in non-tumor tissues (Figure 6A). This evidence concerns the gene PNPLA8 and hepatocellular carcinoma.