CAFs have been reported to contribute to tumor invasiveness and metastasis by secreting a tumorigenic cytokine milieu of TGF-β, stromal-cell-derived factor-1α (SDF-1α), S100A4, fibronectin, and matrix metalloproteinases in the local stromal cell microenvironment [77,78]. The gene discussed is TGFB1; the disease is neoplasm.