IL6 and sarcoma: JNK/p38-MAPK, PVT1/ERG, programmed cell death 4 (PDCD4)/ERK1/2, SOCS3/JAK2/STAT3, TGF-β/COL6A1, IL6/STAT3, PI3K/Akt/mTOR, and Hedgehog in exosomes regulate genes or signaling pathways to promote the migration and metastasis of sarcoma cells [48].