In contrast to previous findings that adenovirus-mediated overexpression of TLR4 in the liver caused insulin resistance in chow-fed wild-type mice [21], in the current study, similar glucose tolerance and insulin sensitivity were observed in Tlr4LoxTB × Alb-Cre and littermate Tlr4LoxTB mice after chronic control liquid diet feeding (Figure 4A,D). This evidence concerns the gene TLR4 and Insulin resistance.