The lack of GBA activity leads to the storage of glycosylceramide (GlcCer, called also glucocerebroside) and glucosylsphingosine (GlcSph, lyso-Gb1, lyso-GL1) in lysosomes of tissue macrophages, which become stimulated and secrete, among other compounds, chitotriosidase, which has been used for more than 20 years (since 1994) as a biomarker of Gaucher disease and an indicator of the progress of its treatment [1,8,9,10,11,12,13]. Here, GBA1 is linked to Gaucher disease.