INSR and metabolic dysfunction-associated steatotic liver disease: Six of the key metagenes—INSR, MAP3K5, NDUFB8, NDUFS1, SDHB, and UQCRC2—are involved in nonalcoholic fatty liver disease [41] (hsa04932), which is caused by a defect in insulin suppression of free fatty acid (FAA) disposal due to the induction of insulin resistance.