DisGeNET analysis highlighted that 27 of the IR key metagenes (~37%)—ALDH6A1, APOB, ARID5B, ATP2B2, ATXN1, B2M, CAT, CFB, CHI3L1, COL8A1, EIF2AK2, FHL2, GATM, HDAC4, HIPK3, HOMER1, IGFBP5, INSR, MAP3K5, MMP9, NDUFS1, RASSF7, REV3L, SLC19A2, UROD, WAS, and ZEB1—were found to be associated with T2D or its related variants such as alloxan, autoimmune, monogenic, neonatal, ketosis-prone, sudden-onset, insipidus, fibrocalculous pancreatic, phosphate, gestational, post-transplant, lipoatrophic, streptozotocin, brittle, and maturity-onset diabetes, among others (Figure 3). This evidence concerns the gene COL8A1 and type 2 diabetes mellitus.