In order to explore the underlying mechanisms by which ICD participated in the pathogenesis of IC/BPS, consensus clustering of IC/BPS patients was performed based on the 19 differentially expressed IRGs, and two different IAMPs were identified: ICD cluster A and ICD cluster B. A high expression of most IRGs was observed in ICD cluster A, except for HSP90AA1, and those upregulated genes were positively correlated to immune features, suggesting that ICD cluster A had the potential to induce ICD and, thus, had a more activated IIME. This evidence concerns the gene HSP90AA1 and Bartsocas-Papas syndrome 1.