Figure 1c shows the chromosomal location of the IRGs. Among the IRGs expressed in the bladder tissues of IC/BPS patients, only ATG5, EIF2AK, IFNB1, HSP90AA1, and NT5E were negatively correlated with most of the other IRGs (Figure 1d). The gene discussed is HSP90AA1; the disease is Bartsocas-Papas syndrome 1.