TNF and cancer: It was reported that dietary compounds or nutraceuticals such as diferuloylmethane (curcumin), plant hytoalexin (resveratrol), pentacyclic triterpenoid isolated from the root of Tripterygium wilfordii (celastrol) radiosensitized different types of cancer cells through the modulation of cell cycle, induction of apoptosis, and the regulation of TNF-α/NFκΒ and MAPK kinases activation [37].