CASP7 and melanoma: The findings of our study confirmed that fucoidan from the brown alga S. cichorioides in combination with pacificusoside D from the starfish S. pacificus at low non-toxic concentrations were able to enhance the apoptosis induced by X-ray irradiation by the activation of initiator caspase 9 and executor caspases 7 and 3, which cleave and thereby inactivate PARP, preventing the repair of DNA damage of 3D melanoma cells SK-MEL-2.