The fucoidan from the brown alga Cladosiphon navaecaledoniae Kylin was reported to enhance the antiproliferative and pro-apoptotic activities of cisplatin, tamoxifen or paclitaxel in breast cancer model MDA-MB-231 and MCF-7 via the regulation of the expression of anti-apoptotic proteins Bcl-xL and Mcl-1 and inhibition of the phosphorylation of protein kinases ERK1/2 and Akt in MDA-MB-231 cells but increased the ERK1/2 phosphorylation in MCF-7 cells [43]. The gene discussed is MAPK3; the disease is breast cancer.