In Gao et al.’ s research, it was confirmed that the acetylation and deacetylation of k263 site of PD-L1 were dynamically regulated by p300 and HDAC2, and modification of acetylation may promote PD-L1 translocation into the nucleus, and are involved in the regulation of IFN, NF-kB, MHC I, and other immune response gene expression by binding to DNA, thereby promoting tumours immune evasion [138]. Here, EP300 is linked to neoplasm.