EP300 and familial pancreatic carcinoma: Ono et al. performed pancreatic cancer cell-related experiments and found that the expression of apoptosis-related proteins such as cleaved caspases 3, 8, and 9 and PARP was increased after p300 interference, and acetylation of H3K27 was also inhibited by C646 treatment, suggesting that p300 may regulate apoptosis of pancreatic cancer cells via its HAT activity [83].