Additionally, the chemotherapeutic drug 5-FU was found to reduce the ability of p300 to bind to chromatin; 5-FU induced H3 and H4 deacetylation and thus their degradation via lysosomes in a study by Du et al. The p300 expression profile was found to correlate with the resistance of colorectal cancer cells to 5-FU [86]. This evidence concerns the gene EP300 and colorectal cancer.