EP300 and breast carcinoma: It has also been demonstrated that DOT1L interacts with the p300/c-Myc complex to enhance EMT-induced stemness properties by recognising promoters such as those of ZEB1 and ZEB2; this promotes DNA methylation and histone acetylation, enhances epithelial−mesenchymal transition (EMT) regulators, and accelerates the malignant progression of breast cancer [65].