The correlation of GABRG2 variants by receptor structural topology with epileptic syndrome type determined a phenotype-location profile (Figure 8B), revealing that more severe forms of epilepsy, such as developmental epileptic encephalopathy (DEE), MAE, GEFS+, and FS, had a higher incidence of variants in more than one structural domain than milder forms, such as CAE and generalized tonic-clonic seizures (GTCS). Here, GABRG2 is linked to epilepsy syndrome.