ADIPOQ and hyperinsulinemic hypoglycemia, familial, 4: Furthermore, while insulin resistance is known to substantially increase the incidence of various diseases, albumin deficiency in mice leads to improved insulin sensitivity and reduced blood glucose levels [8]; the mechanisms appear to include reduced hepatic steatosis, increased adiponectin, and increased glucose transporter expression in adipose tissue, and other adaptations at the gene expression level in adipose tissue that would promote sequestration of FFA into neutral lipid stores [8].