Chai et al. suggested that sevoflurane enhances the expression of acidic leucine-rich nuclear phosphoprotein-32A (ANP32A, the key component of inhibitors of acetyltransferases) by inducing transcription factor CCAAT/enhancer binding protein beta (C/EBPβ), which may inhibit histone acetylation and promote cognitive impairment in aged mice [4]. This evidence concerns the gene CEBPB and Cognitive impairment.