POMC and adrenal gland hyperfunction: Finally, Nadezhdina et al. defined their endpoint, CD recurrence, as one of the following: increased evening salivary cortisol level; no suppression of serum cortisol below 50 nmol/L (1.8 μg/dL) during the 1-mg dexamethasone suppression test; increased 24 h urine free cortisol level; increased concentrations and abnormal secretory rhythms of ACTH and cortisol; or clinical recurrence of hypercorticism [41].