In Model 2, after further controlling for education years, hypertension, diabetes, stroke subtypes, baseline NIHSS score, and Hs-CRP levels, an increased SII index also significantly correlated with 3-month PSCI (per 1-SD increase, OR, 2.341; 95% CI, 1.439–3.809; p = 0.001). This evidence concerns the gene CRP and stroke disorder.