In the western blot assay and immunofluorescence test results of our research, the distinctions between the CRC group and the ALC group mice showed that CR enhanced the expression of Sirt1 in the hippocampus CA1 region of normal aged mice; the differences between the CRS group and ALS group mice indicated that CR-ameliorated POCD may be associated with the increased expression of Sirt1 in the hippocampus CA1 region. The gene discussed is SIRT1; the disease is congenital rubella syndrome.