Our results showed that the morphology of liver cells was significantly altered in CUMS-induced depression in rats and that the increase in the expression of CD68, upregulation of P2X7R/NLRP3/IL-1β expression, and increase in the release of proinflammatory cytokine IL-1β were all improved by EA as well as the intraperitoneal injection of BBG. This evidence concerns the gene IL1B and major depressive disorder.