These genes are involved in the regulation of histone acetylation, methylation or chromatin remodelling, e.g., B-Cell CLL/lymphoma 11 B (BCL11B B-CE), chromodomain helicase DNA-binding protein 7 (CHD7), histone acetyltransferase E1A-binding protein P300 (P300), enhancer of polycomb homolog 2 (EPC2), lysine-specific demethylase 3B (KDM3B), transcriptional repressor GATAD2A, transcriptional co-repressor RERE, and SATB2 [73]. The gene discussed is EPC2; the disease is B-cell chronic lymphocytic leukemia.