ADRA2A and schizophrenia: The upregulation of ADRA2A expression (encoding α2A-adrenoreceptors) in antipsychotic-treated schizophrenia subjects was related to changes in the histone methylation (increased H3K4me3 and H3K27me3) and acetylation (enhanced H4K16ac) levels at the ADRA2A promoter [138].