As alterations in Wnt/β-catenin signalling have been strongly associated with colorectal cancer tumorigenesis, metastasis and recurrence [29], we interrogated the TCGA database to look for KCTD1 and β-catenin misregulation and showed that KCTD1 downregulation was associated with β-catenin overexpression in colorectal cancer patients. Here, KCTD1 is linked to colorectal cancer.