Since the upregulation of β-catenin expression and the consequent activation of the WNT/β-catenin pathway have been correlated to an increase in colorectal cancer [24], we evaluated KCTD1 mRNA expression levels in patients with colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) using data reported in the Cancer Genome Atlas (TCGA). This evidence concerns the gene KCTD1 and colon adenocarcinoma.