Based on the evidence that the upregulation of FGFR2 in dermal fibroblasts has been recognized as a hallmark for the stroma-mediated HNSCC malignant progression [20], we wondered if modulation of this receptor could be also detected in precancerous AK lesions and if this modulation could possibly contribute to AK progression. Here, FGFR2 is linked to head and neck squamous cell carcinoma.