AGT and Hypertension: The generation of mitochondrial reactive oxygen species (ROS) induced by the known vasoconstrictor angiotensin II (Ang II) in ECs [19] has been mechanistically implied in the pathogenesis of hypertension [20,21,22] and previous investigations have evidenced that the upregulation of FGFBP1 can increase oxidative stress signaling, leading to pro-hypertensive effects [23].