MACC1 and breast carcinoma: In conclusion, MACC1 may be involved in the radiation sensitivity of breast cancer cells via the LncRNA FGD5-AS1/miR-497-5p/MACC1 axis, and apoptosis pathway blockade is the main mechanism of LncRNA FGD5-AS1 induced radioresistance, providing a new direction of focus for breast cancer radiotherapy.