MACC1-AS1 promotes proliferation by downregulating PTEN in lung adenocarcinoma cells [97], promoting invasion and proliferation by regulating paired-box gene 8 (PAX8) in hepatoma cells [98], promoting stemness by antagonizing miR-145 [99], and upregulating cyclin-dependent kinase 6 in cervical squamous cell carcinoma [100]. Here, PAX8 is linked to hepatocellular carcinoma.