The involvement of MACC1 in regulating the HGF/c-Met signaling pathway has been confirmed in cancers such as colon cancer [27], breast cancer, ovarian cancer [28,29], lung cancer [30], liver cancer [31], gastric cancer [32], mesocortical tumor [33], malignant brain tumor [34], and kidney cancer [35]. This evidence concerns the gene HGF and colonic neoplasm.