However, human T1D autoantigen-responsive CD8+ T cells (i.e., responsive to islet-specific glucose-6 phosphatase catalytic subunit-related protein) do not show a distinct CRTAM expression profile compared to control-stimulated cells, and no differences on NK T cells were detected in T1D patients, compared to healthy subjects [32,73]. Here, CRTAM is linked to type 1 diabetes mellitus.