AD is a neurodegenerative disorder characterized by the accumulation and deposition of extracellular β-amyloid (Aβ), named senile plaques, and intracellular hyperphosphorylated tau, called neurofibrillary tangles and progressive neuronal loss, especially in the cortex and hippocampus, among others [140] (Table 1). Here, MAPT is linked to Alzheimer disease.