CARM1 and amyotrophic lateral sclerosis: It was also found that a decrease of C9orf72 function is associated with a dysregulation in CARM1 protein levels, FFAs concentration, and NADPH oxidase NOX2 protein levels in C9orf72 knockout (C9KO) MEFs and ALS/FTD (frontotemporal dementia) motor neurons derived from human iPSCs and spinal cord tissues [189].