The hexanucleotide repeat expansion in C9orf72 gene is the most common cause of ALS [190] and C9orf72 promotes the lysosomal degradation of the coactivator-associated arginine methyltransferase 1 (CARM1), which regulates autophagy-lysosomal functions and lipid metabolism downregulating autophagy [189,191]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.