Infiltration of maternal CD8+ T cells has also been identified in pathologies such as chronic chorioamnionitis, infiltration of maternal CD8+ T cells into the chorion, which ultimately can cause pregnancy complications such as PTB, preterm premature rupture of membranes (PPROM), and IUGR, among others [150,167]. The gene discussed is CD8A; the disease is preterm premature rupture of the membranes.