NGF and hereditary disease: To this respect, Hereditary Sensory and Autonomic Neuropathy type V (HSAN V) is an autosomal recessive genetic disorder associated with a point mutation in exon 3 of the NGFB gene, leading to the substitution C661T, i.e., a basic arginine (CGG), into an aromatic tryptophan (TGG) at the position corresponding to residue 100 in mature NGF (R100W) [13].