Furthermore, the propagation of inflammation not only to the periphery but also to the central nervous system has been suggested to accelerate brain aging and is also associated with mental disorders and neurodegenerative-related diseases, including Alzheimer’s disease [7], in which neuronal damage due to microglial activation and decreased brain-derived neurotrophic factor (BDNF) production are prominent features. Here, BDNF is linked to early-onset autosomal dominant Alzheimer disease.