Three scaffolds were combined to form a series of molecules containing a flexible carbon chain: (i) dimethyl fumarate, containing an α,β-unsaturated ketone, a representative structure for Nrf2 activation, (ii) tranilast, an old antiallergic drug with anti-inflammatory properties patented for treating AD [102], and (iii) dithiocarbamate, able to interact with the catalytic active site of AChE. This evidence concerns the gene NFE2L2 and Alzheimer disease.