PROM1 and colon carcinoma: Additionally, the prominin-1-expressing exosomes (prom1-Exo) derived and purified from melanoma and colon carcinoma cells were shown to carry 20 cancer-related miRNAs as well as various prometastatic proteins, including MAPK4K, GTP-binding proteins, CD44, annexin A2 and ADAM10 [206].