Moreover, the recipient cells incubated with leukemia-derived microvesicles exhibited a leukemia-like malignant phenotype with increased global DNA methylation levels and hypermethylation of tumor suppressor genes such as p53 and RIZ1, indicating that microvesicles can initiate the malignant transformation of normal hematopoietic transplants through genomic instability. The gene discussed is TP53; the disease is leukemia.