NFE2L2 and allergic contact dermatitis: As shown in contact hypersensitivity models induced by chemical sensitizers, such as 2,4-dinitrochlorobenzene (DNCB), ear inflammation and lymphocyte proliferation were exacerbated in mice nrf2−/− compared to nrf2+/+, demonstrating an essential role for Nrf2 in controlling allergic contact dermatitis [18].