When adjusting for age, sex, hypertension, smoking, diabetes, IHD, change in CRP levels and SIRT1 level at baseline in a multivariable model, significantly higher SIRT1 levels could still be observed at 48 months in the active group compared with the placebo group, (p = 0.006, Table 2). This evidence concerns the gene SIRT1 and myocardial ischemia.