Aggregates composed of ubiquitinated mSOD1 have been found in fALS patients to inhibit proper protein degradation, leading to neuronal death [135,136,137], however, other mutations in protein degradation genes, such as valosin-containing protein (VCP), OPTN, TBK1, and SQSTM1, have also been found to impact the neuronal protein metabolism of ALS patients [141,142]. The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.