SOD1 and amyotrophic lateral sclerosis: Li HY et al. [128] demonstrated that celastrol reduced cell death by activating mitogen-activated protein kinase (MEK)/extracellular regulated protein kinases (ERK) and phosphoinositide 3-kinase (PI3K)/serine-threonine kinase (AKT) signaling pathways, in G93A- SOD1 transfected NSC34 cells, as a cellular model of ALS.