NFE2L2 and Schnyder corneal dystrophy: Nrf2 was initially discovered as a DNA binding protein in the β-globin locus, and it was concluded after various reports in which tert-butylhydroquinone (tBHQ), simvastatin, and dimethyl fumarate (DMF) were found to be HbF inducing drugs, by enhancing the gamma globin gene expression through Nrf2 activation in human erythroid progenitors and in SCD mice [72,76,85,86].