The described regulatory mechanisms of ferroptosis (LPO caused by iron-mediated oxidative stress and the GPx4-GSH inhibition pathway) may be crucial for the treatment of COVID-19 [11,12], including post COVID-19 syndrome [10], since pathological condition in SARS-CoV-2 infections is strictly associated with mitochondrial dysfunction, iron overload, oxidative stress, and inflammation [9,10,11,12]. Here, GPX4 is linked to COVID-19.