In turn, CD8+ T cells kill tumor cells in the way of ferroptosis by releasing interferon gamma (IFN-γ) and arachidonic acid, which results in increased incorporation of PUFAs into PLs [80], whereas a cholesterol-rich diet aided in increased PUFAs uptake by CD8+ T cells and their death by ferroptosis, which may promote cancer progression [81]. This evidence concerns the gene CD8A and cancer.