BACE1 and Alzheimer disease: However, in CY-09 treated 3×Tg-AD mice, the expressions of these proteins were reversed, with increased expression of sAPPα, PSD95, and synaptophysin; decreased levels of APP, BACE1, sAPPβ and Aβ1-42 were found in comparison to those in the untreated 3×Tg-AD mice, with the p-value lower than 0.05 and 0.01, respectively.