Then, to further explore the underlying mechanism by which NLRP3 inflammasome activation affects insulin resistance, we detected the expression and distribution of the IR-AKT-AS160 insulin signaling pathway-related proteins in NTg, NTg + CY-09, 3×Tg-AD, and 3×Tg-AD + CY-09 mice. The gene discussed is AKT1; the disease is Alzheimer disease.