APP and Alzheimer disease: As shown in Figure 8, compared with the NTg mice, expressions of APP, beta-site app cleaving enzyme 1 (BACE1), sAPPβ, and Aβ1-42 were significantly increased in 3×Tg-AD mice, with the p-value lower than 0.01, 0.05, 0.05, and 0.05.