The results reported in Figure 5c–h show a notable reduction of p-AKT-Ser473 and p-AS160-T642, while significantly increased p-IRS-Ser1101 was found in the 3×Tg-AD mice, with the p-value lower than 0.01, 0.01, and 0.05, respectively. This evidence concerns the gene AKT1 and Alzheimer disease.