HK1 and Alzheimer disease: Although HK activity was remarkably decreased in 3×Tg-AD + CY-09 mice than in NTg + CY-09 mice, it was notably increased in the CY-09-treated 3×Tg-AD mice compared to the non-treated 3×Tg-AD mice, with a p-value lower than 0.05 (Figure 6b).