As demonstrated in Figure 1b–h, compared with NTg mice, the expressions of NLRP3, pro-caspase-1, caspase-1(P20), and IL-1β were significantly increased in 3×Tg-AD mice, with the p-values lower than 0.05 and 0.01 respectively. This evidence concerns the gene NLRP3 and Alzheimer disease.