INSR and Alzheimer disease: As shown in Figure 5a,b, compared with NTg mice, expression of p-IR-Tyr1150 (phosphorylation protein of IR at Tyr1150) relative to IR was significantly decreased in 3×Tg-AD mice, with a p-value lower than 0.01, but the expression was increased after the CY-09 treatment, with a p-value lower than 0.05.