Data presented in Figure 12, reveal that in comparison to NTg mice, the expressions of acetyl coA carboxylase (ACC), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) were greatly increased in the 3×Tg-AD mice, with the p-values all lower than 0.05. The gene discussed is HMGCR; the disease is Alzheimer disease.