The plasma levels of oxylipins produced by COX, LOX and CYP450 enzymes (PGF2α, LXB4, MaR1) are higher in severe NAFLD patients than in patients with mild and moderate NAFLD or in patients without NAFLD, pointing to the coexistence of both inflammation and resolution processes associated with this severe stage of the disease. This evidence concerns the gene LOX and metabolic dysfunction-associated steatotic liver disease.