DLG4 and Alzheimer disease: In terms of postsynaptic density protein 95 (PSD95) and synaptophysin levels, Western blot analysis showed that SeNa significantly promoted the expression of these two proteins in the brains of AD mice (Figure 2h–j), implying that SeNa may have a more significant role in ameliorating synaptic deficits in AD, although synaptophysin levels were also increased in the brains of SeM-treated AD mice (Figure 2h,j).