Mice with knocked-out gpat4 lost weight when fed with a normal diet, and showed some resistance to obesity even when fed with a high-sugar, high-fat diet [60].We observed a similar phenomenon in AGPAT2 knock-down tilapia, which showed inhibited growth compared with that of the control group when fed with a normal diet. Here, GPAT4 is linked to obesity due to melanocortin 4 receptor deficiency.