Therefore, we further analyzed the p-FAK/t-FAK ratios of ISO-1 W, ISO-2 W, and ISO-4 W groups without and with CAN treatment, and the results showed that the reduction of the p-FAK/t-FAK ratio of the ISO-2 W group after CAN treatment is greater than those of ISO-1 W and ISO-4 W groups (Figure 3D). The gene discussed is PTK2; the disease is Crouzon syndrome-acanthosis nigricans syndrome.