Consistent with AOM/DSS treatment, we found that loss of Prx4 reduced the infiltration of CD86+ M1 macrophages, CD163+ M2 macrophages, CD138+ plasma cells, CD4+ T cells, and CD8+ T cells in Prx4−/− colon (Supplementary Figure S4). The gene discussed is PRDX4; the disease is infectious otitis media.