AGT and cardiac hypertrophy: The subpressor dose of Ang II induced cardiac remodeling and dysfunction at 4 months (4 M) and 6 M, reflected by the enhanced cardiac dilation index (left ventricular internal diameter (LVID)) and cardiac hypertrophy index (left ventricular posterior wall (LVPW)), reduced ejection fraction (EF) and fractional shortening (FS), as examined by echocardiography (Figure 1B).