TP53 and non-small cell lung carcinoma: However, p53’s normal function is often disturbed by inactivating or gain-of-function (GOF) mutations in the TP53 gene, which are among the most common genetic lesions found in non-small cell lung cancer (NSCLC) [5] and PDAC [6], and result in the aberrant accumulation of mutant p53 protein and poor patient survival [7].