Preclinical studies in rodent, pig, and monkey models of AD, PD, HD, and ALS [34,249,250,251,252,253,254,255] have also demonstrated that flavonoids have properties that counter neuroinflammation, prevent the neurotoxic effects of pathological protein aggregates of amyloid and hyperphosphorylated tau protein, free radical generation from peroxidation of lipids, and that brain tissues are rich in phospholipids that are susceptible to oxygen radical release during neuroinflammation. The gene discussed is MAPT; the disease is Alzheimer disease.