Overall, chronic treatment with H2S donor could clearly reduce the size of β-amyloid plaques, and reduce activities of c-jun N-terminal kinases (JNK), extracellular signal-regulated kinases and p38 involved in tau phosphorylation, inflammatory response and apoptosis in the cortex and hippocampus, thus finally protecting AD mice against cognitive impairment [104]. Here, MAPT is linked to Alzheimer disease.