DDIT3 and cognitive disorder: Accordingly, it was found that administration of NaHS promoted hippocampal endogenous H2S production in streptozotocin (STZ)-induced diabetic rat models, and significantly ameliorated the diabetic-associated cognitive disorders by inhibiting ER stress, including preventing expressions of glucose-regulated protein 78 (GRP78), cleaved caspase-12, and C/EBP homologous protein (CHOP) [142].