MAPT and Alzheimer disease: For example, it was found that the application of NaHS and Tabiano’s spa water (rich in H2S) can slow down the progression of learning and memory impairment in three experimental models of AD, including brain injection of β-amyloid1-40 (Aβ) or streptozotocin-induced rat models, and in an AD mouse model harboring human transgenes APPSwe, PS1M146V and tauP301L (3xTg-AD mice), by lowering phosphorylation level of tau protein, preventing oxidative and nitrosative stresses in the cerebral cortex, upregulating Bcl-2 and downregulating BAX in the hippocampus [95].