PPARGC1A and Alzheimer disease: The expression of both PGC1α and Nrf2 in the brains was increased with the progression of AD (Figure 7B,C); this could be explained by the fact that the expression of these two transcription regulators might be newly stimulated as a compensation against oxidative stress and neuroinflammation, events that are thought to exacerbate the pathology of AD [54].