BCL2 and acute lymphoblastic leukemia: It is interesting that while the effects of verapamil plus everolimus on p38 MAPK phosphorylation were similar among the T-ALL cell lines (Figure 5B), the effects on cell death were much more evident in Jurkat and TALL−1 cells compared to CEM and DND41 cells (Figure 2A), suggesting that the difference in the outcome of the combination treatment may depend on the status of pathway components positioned downstream from p38 MAPK phosphorylation, such as the expression levels and phosphorylation of pro- and anti-apoptotic BCL-2 family proteins (Figure 5A).