High 3-MST expression was observed in all cell lines. 3-MST also showed better activity than CSE in these cell lines, thus it was also considered as a major protein involved in sulfane sulfur production. H2S produced from CSE induced proapoptotic effects on human melanoma by reducing the activation of ERK/pERK and Apk/pApk pathways and by inhibiting NF-kB mediated anti-apoptotic genes [60]. This evidence concerns the gene EIF2AK3 and melanoma.