PRKG1 and Hyperglycemia: Increased H2S production in bEnd3 cells and plasma H2S levels in rats reduced 3-MST activity [62].Hyperglycemia impaired 3-MP/3-MST/H2S pathway and mitochondrial function; proangiogenic effect of 3-MP in vitro was associated with the activation of Akt and Protein Kinase G (PKG) [62].