ADAM17 and diabetes mellitus: Hu et al. reported that high glucose suppressed the expression level of 3-MST and CSE, hampered the production of H2S in 3t3-L1 adipocytes, and promoted activation of ADAM17, an enzyme with pleiotropic effects and contributions in development of T2DM (Type 2 Diabetes Mellitus), angiopathic and ischemic heart disease, chronic kidney disease, etc. The authors concluded that H2S-producing enzymes including 3-MST are negatively correlated with the expression of ADAM17.