Levels of 3-MST were reduced in the sepsis model [66]. Reduced plasma H2S levels corresponded with increased expression of endoplasmic reticulum stress marker proteins, including p-PERK, p-eIF2, IRE1α, ATF4, and CHOP [66]. Myocardial infarction surgery decreased 3-MST levels [67]. This evidence concerns the gene EIF2AK3 and Sepsis.