Uetake et al. [13], in LOX-1 overexpressing hypercholesterolemic mice fed a high-fat diet containing 3.2% Na+ or chow diet containing 0.2% Na+ for 8 wk, observed an increase in score activity of NAFLD, liver fibrosis (plasma hyaluronic acid, liver fibronectin, and histological analysis), and inflammation (TNF) by the high-sodium diet. This evidence concerns the gene OLR1 and metabolic dysfunction-associated steatotic liver disease.