In addition, a recent study highlighted that heart-specific Lonp1 deficiency in mice causes the fragmentation of mitochondria, aberrant metabolic reprogramming of cardiomyocytes, dilated cardiomyopathy, and HF [67], suggesting an essential role of Lonp1 in regulating mitochondrial dynamics and its importance in normal cardiac physiology. Here, LONP1 is linked to dilated cardiomyopathy.