To shed light on this uncertain scenario, we assessed Lp-PLA2 activity in a large sample including patients with mild cognitive impairment (MCI), Late-Onset Alzheimer’s disease (LOAD), Vascular dementia (VAD), dementia characterized by an overlap between LOAD and VAD (AD-VAD MIXED), other less frequent types of dementia and cognitively healthy controls. Here, PLA2G7 is linked to early-onset autosomal dominant Alzheimer disease.