ACLY and diabetes mellitus: In diabetes, glycolysis provides carbons for de novo lipogenesis, which is under the control of various enzymes [27,28,29]; Adenosine triphosphate citrate lysase (ACLY), Acetyl-CoA carboxylase 1 (ACC1), Fatty acid synthase (FASN), carbohydrate response element binding protein β (ChREBPβ), and sterol regulatory element binding protein 1c (SREBP1c).